Parenting Bulletin    
Recent News |  Archives |  Tags |  Newsletter |  Message Board/Forum |  About |  Links |  Subscribe to ParentingBulletin.com RSS Feed Subscribe


More Articles
Improvements in fuel cell designImprovements in fuel cell design

Rediscovering Venus to find faraway earths

Archaeologists discover bronze remains of Iron Age chariot

Researchers resolve the Karakoram glacier anomaly, a cold case of climate science

Fish tale: New study evaluates antibiotic content in farm-raised fishFish tale: New study evaluates antibiotic content in farm-raised fish

New 3-D display technology promises greater energy efficiencyNew 3-D display technology promises greater energy efficiency

Researchers break nano barrier to engineer the first protein microfiberResearchers break nano barrier to engineer the first protein microfiber

Magnetic mirrors enable new technologies by reflecting light in uncanny ways

Structure of an iron-transport protein revealedStructure of an iron-transport protein revealed

First step: From human cells to tissue-engineered esophagusFirst step: From human cells to tissue-engineered esophagus

Lift weights, improve your memory

Spiders: Survival of the fittest group

Autophagy helps fast track stem cell activationAutophagy helps fast track stem cell activation

Myelin vital for learning new practical skillsMyelin vital for learning new practical skills

More physical activity improved school performanceMore physical activity improved school performance

Around the world in 400,000 years: The journey of the red foxAround the world in 400,000 years: The journey of the red fox

Engineering new vehicle powertrainsEngineering new vehicle powertrains

Active aging is much more than exerciseActive aging is much more than exercise

Study: New device can slow, reverse heart failureStudy: New device can slow, reverse heart failure

Are the world's religions ready for ET?Are the world's religions ready for ET?

Gut bacteria, artificial sweeteners and glucose intoleranceGut bacteria, artificial sweeteners and glucose intolerance

Recreating the stripe patterns found in animals by engineering synthetic gene networksRecreating the stripe patterns found in animals by engineering synthetic gene networks

Laying the groundwork for data-driven scienceLaying the groundwork for data-driven science

Nature's designs inspire research into new light-based technologiesNature's designs inspire research into new light-based technologies

Missing piece found to help solve concussion puzzleMissing piece found to help solve concussion puzzle

Biologists delay the aging process by 'remote control'Biologists delay the aging process by 'remote control'

Geography matters: Model predicts how local 'shocks' influence U.S. economyGeography matters: Model predicts how local 'shocks' influence U.S. economy

Identified for the first time what kind of explosive has been used after the detonationIdentified for the first time what kind of explosive has been used after the detonation

Copied from nature: Detecting software errors via genetic algorithmsCopied from nature: Detecting software errors via genetic algorithms

Rare pregnancy condition programs babies to become overweight in later life (7/2/2013)

<
Tags:
babies, balance, birth, boys, college, diabetes, diet, environment, exercise, girls, health, infants, lead, mothers, obesity, pregnancy, work

Babies born to mothers who suffer from a rare metabolic complication during pregnancy are programmed to be overweight, according to a study published today in the Journal of Clinical Investigation.

The study is the first to look at the long term effects on babies born to mothers with intrahepatic cholestasis of pregnancy (ICP), also called obstetric cholestasis, a rare complication of pregnancy characterised by the build-up of bile acids in the bloodstream.

The findings add to the strong evidence that the environment that babies are exposed to in the womb is a major cause of metabolic diseases in adults.

ICP can affect up to one in 50 pregnant women in different populations. It is caused by disruption in the flow of bile, a fluid produced by the liver to help with the digestion of fats. This can result in some leakage of bile, and in particular bile salts, into the bloodstream leading to symptoms including persistent itching and complications for both mother and baby.

The researchers looked at a cohort of babies born in Northern Finland between 1985 and 1986 and identified 45 babies who were born to mothers with ICP who were of healthy weight and had no other known diseases or complications, such as diabetes.

Although there were no differences in the birth weights of these babies compared with infants born during the same period from normal pregnancies, the team found that by age sixteen, boys born from cholestatic pregnancies had a much higher body mass index, by up to four points. They also had higher levels of the hormone insulin after a period of fasting, a symptom of type 2 diabetes. Whilst the effect in girls was smaller, waist measurements from girls of the same age born to mothers with cholestasis were increased by up to 9cm and hip measurements by up to 5cm compared with girls born from normal pregnancies.

To further investigate the effects of cholestasis during pregnancy on the health of the offspring, the researchers created a mouse model of the disease by supplementing the diet of normal mice with cholic acid, a type of bile acid. Mice born from these pregnancies were also more prone to obesity and diabetes, confirming the findings from the human studies.

Dr Georgia Papacleovoulou, first author of the study from Imperial College London, explains: "This is the first evidence that cholestasis during pregnancy can have long-term effects on the health of the baby as it grows into adulthood."

Both the human and mouse studies revealed an increase in fats and excessive cholesterol transport in placentas from mothers with cholestasis compared with healthy mothers, consistent with a disruption in the metabolism of fats. The researchers propose that this shift in the nutrients supplied by the mother is likely to affect the energy balance in the unborn baby, something that could continue after the baby is born, resulting in an altered metabolism in adult life that could give rise to diseases such as obesity and diabetes.

Using another mouse model, the researchers showed that feeding bile salts to mice during pregnancy resulted in chemical changes to the DNA of the offspring, or epigenetic changes.

Professor Catherine Williamson, lead author of the study from Imperial College London and King's College London, said: "We don't yet know the exact mechanisms of how the increase in bile salts in the mothers' blood programs the unborn baby towards metabolic disease but it seems likely that epigenetics plays a role. We need to do more experiments to work out how these chemical changes to the DNA of the baby affect its ability to metabolise fats."

Dr Alison Cave, Head of Cellular, Developmental and Physiological Sciences at the Wellcome Trust, said: "We're in the grips of an epidemic of obesity and diabetes and this study adds to the increasing evidence which suggests that it may not be explained by unhealthy diets and lack of exercise alone. We know that the environment that babies are exposed to before they are born can have a huge impact on their health in later life. Studies like this are important to help us develop interventions that might be able to prevent these diseases arising in young adults."

Note: This story has been adapted from a news release issued by the Wellcome Trust

Post Comments:

Search
New Articles
Certain parenting tactics could lead to materialistic attitudes in adulthoodCertain parenting tactics could lead to materialistic attitudes in adulthood

Even expectant dads experience prenatal hormone changes

A 2-minute delay in cutting the umbilical cord leads to a better development of newborns

Study finds low weight gain in pregnant women reduces male fetal survivalStudy finds low weight gain in pregnant women reduces male fetal survival

Prenatal exposure to common household chemicals linked with substantial drop in child IQ

Are you helping your toddler's aggressive behavior?

Punishing kids for lying just doesn't work

Higher birth weight indicates better performance in school

Are the benefits of breast milk stimulant worth the risk?

Many chest X-rays in children are unnecessaryMany chest X-rays in children are unnecessary

Why does physical activity during childhood matter?

Heavier newborns show academic edge in school

Why don't children belong to the clean plate club?Why don't children belong to the clean plate club?

New study examines the effect of timing of folic acid supplementation during pregnancy

Full-day preschool linked with increased school readiness compared with part-day



Archives
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010




Science Friends
Agricultural Science
Astronomy News
Biology News
Biomimicry Science
Cognitive Research
Chemistry News
Tissue Engineering
Cancer Research
Cybernetics Research
Electonics Research
Forensics Report
Fossil News
Genetic Archaeology
Genetics News
Geology News
Nanotech News
Microbiology Research
Physics News
  Archives |  Submit News |  Advertise With Us |  Contact Us |  Links
Use of this site constitutes acceptance of our Terms of Service and Privacy Policy. All contents © 2000 - 2019 ParentingBulletin.com. All rights reserved.