Parenting Bulletin    
Recent News |  Archives |  Tags |  Newsletter |  Message Board/Forum |  About |  Links |  Subscribe to ParentingBulletin.com RSS Feed Subscribe


More Articles
Improvements in fuel cell designImprovements in fuel cell design

Rediscovering Venus to find faraway earths

Archaeologists discover bronze remains of Iron Age chariot

Researchers resolve the Karakoram glacier anomaly, a cold case of climate science

Fish tale: New study evaluates antibiotic content in farm-raised fishFish tale: New study evaluates antibiotic content in farm-raised fish

New 3-D display technology promises greater energy efficiencyNew 3-D display technology promises greater energy efficiency

Researchers break nano barrier to engineer the first protein microfiberResearchers break nano barrier to engineer the first protein microfiber

Magnetic mirrors enable new technologies by reflecting light in uncanny ways

Structure of an iron-transport protein revealedStructure of an iron-transport protein revealed

First step: From human cells to tissue-engineered esophagusFirst step: From human cells to tissue-engineered esophagus

Lift weights, improve your memory

Spiders: Survival of the fittest group

Autophagy helps fast track stem cell activationAutophagy helps fast track stem cell activation

Myelin vital for learning new practical skillsMyelin vital for learning new practical skills

More physical activity improved school performanceMore physical activity improved school performance

Around the world in 400,000 years: The journey of the red foxAround the world in 400,000 years: The journey of the red fox

Engineering new vehicle powertrainsEngineering new vehicle powertrains

Active aging is much more than exerciseActive aging is much more than exercise

Study: New device can slow, reverse heart failureStudy: New device can slow, reverse heart failure

Are the world's religions ready for ET?Are the world's religions ready for ET?

Gut bacteria, artificial sweeteners and glucose intoleranceGut bacteria, artificial sweeteners and glucose intolerance

Recreating the stripe patterns found in animals by engineering synthetic gene networksRecreating the stripe patterns found in animals by engineering synthetic gene networks

Laying the groundwork for data-driven scienceLaying the groundwork for data-driven science

Nature's designs inspire research into new light-based technologiesNature's designs inspire research into new light-based technologies

Missing piece found to help solve concussion puzzleMissing piece found to help solve concussion puzzle

Biologists delay the aging process by 'remote control'Biologists delay the aging process by 'remote control'

Geography matters: Model predicts how local 'shocks' influence U.S. economyGeography matters: Model predicts how local 'shocks' influence U.S. economy

Identified for the first time what kind of explosive has been used after the detonationIdentified for the first time what kind of explosive has been used after the detonation

Copied from nature: Detecting software errors via genetic algorithmsCopied from nature: Detecting software errors via genetic algorithms

NIH program explores the use of genomic sequencing in newborn healthcare (9/11/2013)

<
Tags:
development, doctors, health, infants, lead, medicine, newborns, parents, technology, work

Can sequencing of newborns' genomes provide useful medical information beyond what current newborn screening already provides? Pilot projects to examine this important question are being funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Human Genome Research Institute (NHGRI), both parts of the National Institutes of Health. Awards of $5 million to four grantees have been made in fiscal year 2013 under the Genomic Sequencing and Newborn Screening Disorders research program. The program will be funded at $25 million over five years, as funds are made available.

"Genomic sequencing has potential to diagnose a vast array of disorders and conditions at the very start of life," said Alan E. Guttmacher, M.D., director of NICHD. "But the ability to decipher an individual's genetic code rapidly also brings with it a host of clinical and ethical issues, which is why it is important that this program explores the trio of technical, clinical, and ethical aspects of genomics research in the newborn period."

The awards will fund studies on the potential for genome and exome sequencing to expand and improve newborn health care. Genomic sequencing examines the complete DNA blueprint of the cells, and exome sequencing is a strategy to selectively sequence exons, the short stretches of DNA within our genomes that code for proteins.

"We are at a point now where powerful new genome sequencing technologies are making it faster and more affordable than ever to access genomic information about patients," said Eric D. Green, M.D., Ph.D., director of NHGRI. "This initiative will help us better understand how we can appropriately use this information to improve health and prevent disease in infants and children."

Programs currently screen almost all of the more than 4 million infants born in the United States each year. Until now, the testing of DNA has not been a first-line newborn screening method, but has been used to confirm the screening results of some disorders, such as cystic fibrosis.

Each of the new awards will consist of three parts: Genomic sequencing and analysis; research related to patient care; and the ethical, legal and social implications of using genomic information in the newborn period. Teams of researchers will work to further the understanding of disorders that appear in newborns and to improve treatments for these diseases using genomic information. The four grantees are:

Brigham and Women's Hospital and Boston Children's Hospital, Boston

Principal Investigators: Robert Green, M.D., and Alan Beggs, Ph.D.

This research project will accelerate the use of genomics in pediatric medicine by creating and safely testing new methods for using information obtained from genomic sequencing in the care of newborns. It will test a new approach to newborn screening, in which genomic data are available as a resource for parents and doctors throughout infancy and childhood to inform health care. A genetic counselor will provide the genomic sequencing information and newborn screening results to the families. Parents will then be asked about the impact of receiving genomic sequencing results and if the information was useful to them. Researchers will try to determine if the parents respond to receiving the genomic sequencing results differently if their newborns are sick and if they respond differently to receiving genomic sequencing results as compared to current newborn screening results. Investigators will also develop a process for reporting results of genomic sequencing to the newborns' doctors and investigate how they act on these results.

Children's Mercy Hospital - Kansas City, Mo.

Principal Investigator: Stephen Kingsmore, M.D.

Many newborns require care in a neonatal intensive care unit (NICU), and this group of newborns has a high rate of disability and death. Given the severity of illness, these newborns may have the most to gain from fast genetic diagnosis through the use of genomic sequencing. The researchers will examine the benefits and risks of using rapid genomic sequencing technology in this NICU population. They also aim to reduce the turnaround time for conducting and receiving genomic sequencing results to 50 hours, which is comparable to other newborn screening tests. The researchers will test if their methods increase the number of diagnoses or decrease the time it takes to reach a diagnosis in NICU newborns. They will also study if genomic sequencing changes the clinical care of newborns in the NICU. Additionally, the investigators are interested in doctor and parent perspectives and will try to determine if parents' perception of the benefits and risks associated with the results of sequencing change over time.

University of California, San Francisco

Principal Investigator: Robert Nussbaum, M.D.

This pilot project will explore the potential of exome sequencing as a method of newborn screening for disorders currently screened for and others that are not currently screened for, but where newborns may benefit from screening. The researchers will examine the value of additional information that exome sequencing provides to existing newborn screening that may lead to improved care and treatment. Additionally, the researchers will explore parents' interest in receiving information beyond that typically available from newborn screening tests. The research team also intends to develop a participant protection framework for conducting genomic sequencing during infancy and will explore legal issues related to using genome analysis in newborn screening programs. Together, these studies have the potential to provide public health benefit for newborns and research-based information for policy makers.

University of North Carolina at Chapel Hill

Principal Investigators: Cynthia Powell, M.D., M.S., and Jonathan Berg, M.D., Ph.D.

In this pilot project, researchers will identify, confront and overcome the challenges that must be met in order to implement genomic sequencing technology to a diverse newborn population. The researchers will sequence the exomes of healthy infants and infants with known conditions such as phenylketonuria, cystic fibrosis or other disorders involving metabolism. Their goal is to help identify the best ways to return results to doctors and parents. The investigators will the explore the ethical, legal and social issues involved in helping doctors and parents make informed decisions, and develop best practices for returning results to parents after testing. The researchers will also develop a tool to help parents understand what the results mean and examine extra challenges that doctors may face as this new technology is used. This study will place a special emphasis on including multicultural families.

"These pilot studies build upon the nation's very successful public health newborn screening programs that reach almost all infants born in the United States," said Dr. Guttmacher. "We will carefully evaluate the use of genomic data in newborns, including how best to deliver genomic information to parents and healthcare providers, to see how we can improve our care of children, who are, of course, our future."

The following numbers represent the newly funded grants: 1U19HD077693-01; 1U19HD077632-01; 1U19HD077627-01; and 1U19HD077671-01.

Note: This story has been adapted from a news release issued by the NIH/National Human Genome Research Institute

Post Comments:

Search
New Articles
Certain parenting tactics could lead to materialistic attitudes in adulthoodCertain parenting tactics could lead to materialistic attitudes in adulthood

Even expectant dads experience prenatal hormone changes

A 2-minute delay in cutting the umbilical cord leads to a better development of newborns

Study finds low weight gain in pregnant women reduces male fetal survivalStudy finds low weight gain in pregnant women reduces male fetal survival

Prenatal exposure to common household chemicals linked with substantial drop in child IQ

Are you helping your toddler's aggressive behavior?

Punishing kids for lying just doesn't work

Higher birth weight indicates better performance in school

Are the benefits of breast milk stimulant worth the risk?

Many chest X-rays in children are unnecessaryMany chest X-rays in children are unnecessary

Why does physical activity during childhood matter?

Heavier newborns show academic edge in school

Why don't children belong to the clean plate club?Why don't children belong to the clean plate club?

New study examines the effect of timing of folic acid supplementation during pregnancy

Full-day preschool linked with increased school readiness compared with part-day



Archives
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010




Science Friends
Agricultural Science
Astronomy News
Biology News
Biomimicry Science
Cognitive Research
Chemistry News
Tissue Engineering
Cancer Research
Cybernetics Research
Electonics Research
Forensics Report
Fossil News
Genetic Archaeology
Genetics News
Geology News
Nanotech News
Microbiology Research
Physics News
  Archives |  Submit News |  Advertise With Us |  Contact Us |  Links
Use of this site constitutes acceptance of our Terms of Service and Privacy Policy. All contents © 2000 - 2020 ParentingBulletin.com. All rights reserved.